The effect of intra-amygdalar leptin administration on anxiety, depression and learning behaviors in rats

Leptin is released by adipose tissue. can cross the blood–brain barrier and bind to receptors on neurons in brain areas exert its biological function when into circulation. This study aimed determine influences of intra-amygdalar administration high low doses leptin anxiety, depression, learning behaviors rats. In experimental protocol I, injection (0.1 1 μg/ kg) saline were administered 30 min before behavioral tests. Then, animals exposed open field, elevated plus maze, Porsolt Morris water maze tests for measuring behaviors. 2, cerebrospinal fluids all groups collected microdialysis method then analyzed HPLC. The effect dose was significant field. test. mobility center Porsolt. A group had spent less time around platform than controls HPLC analysis showed that amount serotonin glutamate amygdala region increased after administration. Intra-amygdalar may decrease anxiety depression-like behavior rats increasing levels amygdala.